Minoxidil (mi NOX i dill) is a clinically supported medication that’s proven to both improve hair growth and slow down the hair loss process. It’s most effective for regrowth along the top of your head and crown. According to clinical studies, it can actually make hair up to 35% thicker!

This hair-growth champion comes in a few different forms, including topical foam and solution (generic RogaineⓇ), as well as our compounded Minoxidil+ Spray. In recent years, there have been a lot of studies revolving around oral minoxidil, as well. The information below will help you understand the different forms a provider may prescribe.

Oral Minoxidil

Oral minoxidil started in the 70s as a treatment for high blood pressure. However, hypertrichosis – excessive hair growth – was found to be a common side effect among its users. This quickly led to the development of topical formulas for hair loss – more on those options below.

The standard dosage for patients taking the drug for high blood pressure is 10 to 40 mg daily. Early experiments of 10-40 mg oral minoxidil for hair loss caused unacceptable side effects, so people shifted focus to topical formulas, companies sought U.S. Food and Drug Administration (FDA) approval for topical options, and they became the norm.

However, a few years ago, Australian dermatologist Rod Sinclair began investigating oral dosages as low as 0.625 and 1.25 mg for hair loss. These dosages were successful at stopping hair shedding and regrowing hair with fewer side effects. This is what’s now referred to as “Low Dose Oral Minoxidil.” Although the FDA hasn’t approved Low Dose Oral Minoxidil, the FDA allows providers to prescribe this drug for hair loss, if they think it is clinically appropriate.

Treatment

Low Dose Oral Minoxidil is in tablet form and is taken by mouth. It is available only with your provider’s prescription. Different doses have been used to treat hair loss, ranging from 1.25 mg to 5 mg daily in men and 0.25 mg to 2.5 mg daily in women, so what low dose oral minoxidil is prescribed will depend on what your provider deems appropriate for you. Results may be visible within four to six months, but could also take up to six to eight months, and tend to be stable at the one-year mark.

Side Effects

All medications have side effects, some serious. The potential adverse side effects associated with low dose oral minoxidil include

  • Hypertrichosis (excessive hair growth),
  • Lightheadedness,
  • Fluid retention,
  • Tachycardia (fast heart rate),
  • Headache,
  • Periorbital edema (swelling around the eyes), and
  • Insomnia.

If you would like to learn more about low dose oral minoxidil, FDA approved labeling is available here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: HTTPS://WWW.FDA.GOV/SAFETY/MEDWATCH /default.htm or call 1-800-FDA-1088.

Minoxidil Foam

It wasn’t until the early aughts that a foam version of minoxidil hit the shelves. Minoxidil foam is thought to be the gentler version because the liquid version of minoxidil contains propylene glycol, a water-soluble alcohol that can sometimes cause redness and irritation on the skin. Other than that difference, the two versions have the same efficacy.

Treatment

Some people find minoxidil foam to be the easiest topical option because it can be applied by hand, whereas the minoxidil solution requires a dropper tool. Minoxidil foam needs to be applied regularly. If a dose is missed, it should be applied as soon as possible. (Though patients can hold off and just apply the next dose as scheduled, if it’s almost time for it.) Men typically notice hair regrowth results within 4-6 months of consistent use, but results may vary.

Side Effects

Side effects of minoxidil foam can include redness, irritation, and itching at the site of application. If you would like to learn more about minoxidil foam, FDA approved labeling is available here.

Minoxidil Solution

The liquid version was the first to become a commercial success in the 80’s.

Treatment

It is dispensed from a bottle via a dropper directly to your scalp. Generally, people with sensitive skin should consider minoxidil foam because it is a gentler treatment option that is less likely to cause allergies or irritation. The good news is the solution has about the same results timeline as the foam. Men typically notice hair regrowth results within 4-6 months of consistent use, but results may vary.

Side Effects

The most common side effect with minoxidil solution is skin irritation. If you would like to learn more about minoxidil solution, FDA approved labeling is available here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: HTTPS://WWW.FDA.GOV/SAFETY/MEDWATCH /default.htm or call 1-800-FDA-1088.

Minoxidil+ Hair Regrowth Spray

Treatment

Minoxidil+ Hair Regrowth Spray is a pre-measured spray you spritz on your scalp just once a day. You may enjoy this drip-free mist if you don’t like the weighted feeling of a serum or if you worry about getting product on your sheets at night. It also has about the same results timeline as the foam and solution. Men typically notice hair regrowth results within 4-6 months of consistent use, but results may vary.

Side Effects

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: HTTPS://WWW.FDA.GOV/SAFETY/MEDWATCH /default.htm or call 1-800-FDA-1088

What’s the best type for hair loss?

There are a few different versions of minoxidil for hair loss. Oral minoxidil may be on the up and up, but the FDA-approved topical products are tried and true. The key is consistent use, regardless of what form a provider prescribes. In addition, there are more options beyond just minoxidil. For example, for patients who are experiencing overall hair loss and a receding hairline, providers will often recommend taking minoxidil together with another clinically supported hair-boosting medication, finasteride**.

In general, finding what’s right for you comes down to your preferences, your maintenance routine, and what your provider thinks is the optimal option to help you achieve your dream hair goals.


The following blog contains information about products that may or may not have been approved by the U.S. Food & Drug Administration as safe and effective for the condition being discussed. By providing such educational content, Thirty Madison, Inc. in no way supports or endorses the use of these products for such conditions. Such a determination must be made by a licensed clinician who may prescribe these products for such conditions because, in his, her, or their clinical judgment, use of the product is medically appropriate. The FDA approved product labeling may be found at https://dailymed.nlm.nih.gov.

** Finasteride, Rx only, treats men’s hair loss, and may cause side effects, including sexual side effects and depression. Finasteride should never be taken by women. If you would like to learn more about finasteride, please see the full prescription information here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch: https://www.fda.gov/Safety/MedWatch/default.htm or call 1-800-FDA-1088.) If you’re experiencing a mental health crisis, please call 911 or go to your nearest emergency department. If you are contemplating suicide, call 911 or call/text the National Suicide and Crisis Lifeline at 988. These services are available 24/7.

The information provided in this article is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided in this article for specific medical advice. If you have any questions or concerns, please talk to your medical provider.

Oral Minoxidil Tablets (1.25mg, 2.5mg, 3.75mg, & 5mg), Rx only, have not been approved by the FDA as safe and effective to treat treat hair loss and increase hair growth, however studies have shown promising results for slowing hair loss, improving regrowth, and increasing total hair count. This drug may also cause side effects including excessive hair growth, lightheadedness, fluid retention, fast heart rate, headache, swelling around the eyes, and insomnia. See more information here. By providing this content, Thirty Madison, Inc. in no way supports or endorses the use of this product for such condition(s). Only a licensed clinician may prescribe oral minoxidil for hair loss if in their clinical judgment use of the product is medically appropriate. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Minoxidil Solution 5%, intended to treat male pattern baldness may cause side effects, including chest pain or palpitations, dizziness, skin rash, blisters or itching, sudden weight gain and swelling of hands and feet. If you would like to learn more about Minoxidil Solution 5%, please see prescribing information here. You are encouraged to report negative side effects to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Minoxidil Foam 5%, intended to treat male pattern baldness may cause side effects, including chest pain or palpitations, dizziness, skin rash, blisters or itching, sudden weight gain and swelling of hands and feet. If you would like to learn more about Minoxidil Foam 5%, please see prescribing information here. You are encouraged to report negative side effects to the FDA. Visit MedWatch or call 1-800-FDA-1088.

Finasteride Tablets 1mg, Rx only, treats male pattern baldness in men only. Finasteride may cause side effects including some form of sexual side effects, such as less desire for sex, difficulty in achieving an erection, or a decrease in the amount of semen released during sex. Other potential side effects of Finasteride include swelling or tenderness in the breasts or pain or fluids leaking from the nipple, pain in the testicles, inability to urinate, or depression. If you would like to learn more about Finasteride, please see the full prescription information, here. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch or call 1-800-FDA-1088.

If you’re experiencing a mental health crisis, please call 911 or go to your nearest emergency department. If you are contemplating suicide, call 911 or call/text the National Suicide and Crisis Lifeline at 988. These services are available 24/7.

Individual results may vary. Important drug safety and benefits information on Minoxidil+ Hair Regrowth Spray (minoxidil 5%, 0.2% caffeine, 0.1% melatonin, 0.01% tretinoin), an Rx only compound drug, can be found here. Minoxidil+ Hair Regrowth Spray has not been FDA-approved or evaluated for safety, efficacy, or quality but can be used to treat male pattern baldness, and may cause side effects including chest pain or palpitations, dizziness, skin rash, blisters or itching, sudden weight gain and swelling of hands and feet. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

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